Since the beginning of time mankind has wanted to live longer, and I guess to some extent we have, although many would argue that our ‘health-span’ hasn’t increased to any meaningful extent. By this, I mean that a larger proportion of the population are living to a higher age, but their quality of life is not that inspiring!
For too long we have looked to mass produced pharmaceuticals to address issues when they arise – whether this be wasting muscles, gut health, bone density, or weak cell regeneration that is a catalyst for a multitude of diseases and chronic conditions. This is the ‘reactive’ approach – when you get sick let’s fix it, rather than how do we avoid getting sick (the ‘proactive’ approach).
Thankfully a growing number of medical and health professionals are now implementing the vastly superior ‘proactive’ strategy of tailored preventative functional medicine to keep their patients healthy and happier for longer by preventing health issues before they arise. Functional medicine recognises that one size doesn’t fit all, and humans are individuals that require tailored solutions in order to provide an optimal outcome, and this is typically done in a holistic view.
Additionally, medical and health professionals are adopting, with outstanding success, programs tailored to the individual’s unique physiology, engaging natural supplements and cutting-edge science, including tailored peptide protocols.
When it comes to anti-ageing there is one name that is leading the thinking, and that is David Sinclair. This Australian-born Harvard Medical School professor of genetics has had countless discoveries published in some of the most respected scientific journals and been awarded many scientific prizes and honors.
In his book Lifespan Mr Sinclair outlines why ageing is a disease that can be cured – this is backed by deep critical thinking and scientific evidence that has many thought-leaders re-thinking the direction of our healthcare framework.
When it comes to bio-hacking to improve ‘health-span’ peptides are playing an increasingly important role in this space, with peptide clinics are receiving a growing number of queries on a daily basis from people interested in anti-ageing peptides and what ‘stacks’ work best.
In this article I’ll walk you through the most powerful anti-ageing stack. This stack combines Growth Hormone Releasing Peptides (GHRP) and Growth Hormone Releasing Hormone (GHRH) stacked with Insulin Like Growth Factor (IGF-1 LR3).
OK – let’s start with GHRP
GHRP is short for “Growth Hormone Releasing Peptide”, which are the chemical class of growth hormones in the category of drugs known as GH Secretagogues. They stimulate the body's natural release of the natural growth hormone (GH), primarily by stimulating the pituitary gland to produce more Growth Hormone. The four most common GHRPs are Ipamorelin, GHRP-2, GHRP-6, and Hexarelin – in order of strength. These guys are well known for reducing body fat, increase lean muscle mass, improve cellular repair and skin health, and supporting improved sleep cycles.
Now let’s move onto the GHRH….
These Growth Hormone Releasing Hormones (GHRHs) basically causes the release of another hormone, in addition to stimulating any GHRP to increase the release of GH. So it’s now becoming clear why it is important to stack your GHRH with GHRP to super charge the increase in GH. In summary GHRP's release a pulse of GH, and then the GHRH's release and amplify this pulse.
The most common GHRH used is CJC-1295. This can be compounded with or without DAC (drug affinity complex). That said, CJC-1295 without DAC is viewed as a better stack as it’s release timing is perfect matched with the GHRP release.
Now let’s add the GH: IGF-1 LR3
IGF-LR3 is short for “Insulin-like Growth Factor – 1 Long Arg3”. IGF-LR3 is a polypeptide hormone that contains some of the same molecular structure as insulin, and closely mimics the anabolic effects of insulin.
IGF-LR3 responds to signals from growth hormone (GH) and is the most potent growth factor in the human body, which is why it is regularly used in the bodybuilding community. It is well known for rapid fat loss, anti-ageing, recovery speed, improve muscle performance and muscle mass, improved sleep cycles, among many other benefits.
So how does this stack work?
Let’s start with the GHRH and GHRP – this is the easy part as most reputable peptide clinics will supply these as a perfectly balanced stack in the form of a transdermal cream or a vial for subcutaneous injection (injection being the preferred method). For example, the peptide compound is either CJC-1295 combined with either Ipamorelin, GHRP-2, or GHRP-6 – and this is in the order of strength, with CJC-1295/GHRP-6 know for superior lean muscle mass as it does encourage increase hunger. As a base the CJC-1295/Ipamorelin is seen as the perfect all-rounder.
Moving on from this the stack introduces IGF-1 LR3, which are all taken together on a daily basis, generally following a protocol of 5 days on and two days off over a 10-week cycle. A good peptide clinic will offer professional medical advice on protocols in order to tailor the optimal stack for the individual.
To round this stick off we add Hexarelin which is the most potent GHRP and delivers an impressive GH pulse when combined with the IGF-1 LR3. Hexarelin has a high rate of desensitisation, and as such should only be used for a short period of time, which is typically towards the end of your cycle.
BIOV8 has worked with our doctors to pull together ‘goal focus’ stacks (or bundles) that eliminate the guess work.
In summary this stack delivers double the effect of either the GHPH or GHRP on their own, then adding the IGF stimulates optimal growth hormone production and accelerates muscles gains, fat loss, recovery and the other benefits of using peptides like this.
Our team is constantly researching emerging peptide research to design these cutting-edge peptide stacks for optimal results, using uncompromising quality peptides.
If you have any questions reach out to our friendly team on care@BIOV8.com.au
The BIOV8 Team
Note: this is not to be taken, interpreted or construed as medical advice. Please talk with a licensed medical professional about this. These are just general discussion points and not a prescription or a diagnosis or any form of health care in any way.