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    AOD-9604

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    What is AOD-9604

    AOD-9604 (Advanced Obesity Drug) was originally developed by Professor Frank Ng at Monash University in Australia in the 1990s, with the intent of finding an anti-obesity drug that had powerful fat burning effects of human growth hormone (HGH) without the muscle-building effect.

    AOD-9604 peptide is considered the most potent fat loss peptide supplements.

    BIOV8 uses only premium pharmaceutical grade in all of our products.

    Snapshot

     AOD-9604 peptide is considered the most potent fat loss peptide supplements.AOD-9604 (Advanced Obesity Drug) according to clinical studies, has it’s remarkable power found in its ability to regulate your body's metabolism. By stimulating the metabolism's natural fat-burning process, it triggers the release of fat from obese fat cells, while also working to decrease the growth of new fat in the surrounding fat cells. It works by mimicking the way natural growth hormone regulates fat metabolism without the adverse effects on blood sugar. AOD-9604 stimulates lipolysis (the breakdown of fat) and inhibits lipogenisis (the transformation of non-fat food materials into body fat).

    Studies undertake byMonash University discovered the fat-reducing effects of the AOD-9604 appear to be controlled by a small region near one end of the Growth Hormone molecule, stimulating the breakdown of fat. Widely considered a powerful fat loss peptide without harmful side effects.


    AOD-9604 peptide possesses many other regenerative properties associated with growth hormone. Currently trials are underway to show the application of AOD-9604 in osteoarthritis, Hypercholesterolemia, bone and cartilage repair. AOD-9604 has an excellent safety profile, recently obtaining Human GRAS status in the USA.

    Potential benefits
    • Powerful fat burning peptide that specifically targets and reduces the stubborn body fat
    • Increases muscle mass
    • Favours and triggers fat release from obese fat cells rather than the lean
    • Efficiently increases IGF-1 levels resulting in fat reduction
    • Promotes energy expenditure
    • Improves lipid profiles and lipolytic activity 
    Key effects
    • Mimics the body’s natural growth
    • No adverse effects on blood sugar nor body growth
    • AOD-9604 stimulates & increases lipolysis
    • Inhibits lipogenesis - the transformation process of non-fatty food into body fat

    AOD-9604 does not increase appetite or raise cortisol, unlike the GHRP family (GHRP-6, GHRP-2 or Hexarelin)


      How it works

      AOD-9604 promotes the fat loss effects exhibited those received from growth hormone supplementation. At the same time it does not increase food consumption, blood sugar or insulin resistance. (Heffernan 2001, Heffernan 2001, Ng 2000). AOD-9604 stimulates fat breakdown (lipolysis) and fat burning (oxidation), through a mechanism that doesn’t use the hGh receptor. 

      One theory suggests that there is an unidentified AOD-9604 receptor located on fat cells and that a similar molecule is one of the peptides released by the pituitary somatroph cell when it releases Growth Hormone. Multiple lab studies suggest that AOD-9604 triggers and favours the release of fat from obese fat cells more than those that are lean. This reduces the accumulation of new fat in all fat cells and increases fat burning. The exceptional function of this fat loss peptide is its ability to reduce visceral fat stores. Visceral fat is the abdominal fat that gets deposited throughout the abdomen, blanketing and smothering vital organs. 

      Possible side effects
      • Headache
      • Diarrhoea
      • Nausea
      Purity, Content, and Dosage

      Purity: >98% (HPLC on request) 

      Content: 1200mcg/ml subcutaneous injectable provided in a 5ml vial. 

      Suggested dosage: Inject 0.25ml subcutaneously in the morning daily then enjoy a solid cardio session. Up to 40 days per cycle

      Transdermal Option: 300mcg/mL x 50mL - Apply 1mL daily for 40 days.

      Technical overview and history

      AOD-9604 is a modified peptide fragment of HGH known as GH Frag 176-191 or AOD-9604. AOD-9604 is a peptide fragment of the C-terminus of hGH. AOD-9604

      Molecular Formula: C78H123N23O23S2 

      Sequence: Tyr-Leu-Arg-Ile-Val-Gln-Cys-Arg-Ser-Val-Glu-Gly-Ser-Cys-Gly-Phe-OH

      Molecular Weight:1815.08

      AOD-9604 was initially developed in the 1990’s by Professor Frank Ng at Monash University in Australia. The intended purpose for AOD-9604 was to act as one of the best anti-obesity drugs which had the fat burning effects of (HGH) without the coinciding muscle-building effects.


      Clinical studies and research

      Safety and Tolerability of the Hexadecapeptide AOD-9604 in Humans Heike Stier, Evert Vos, David Kenley (http://www.jofem.org/index.php/jofem/article/view/157/194)

      Background: AOD-9604 is a safe peptide fragment of the C-terminus of the hGH molecule that provides activity related to fat loss. In this study, AOD-9604 and its safety data, obtained in clinical trials are reviewed. Methods: There were a total of six trials performed with AOD-9604, all of which were randomised, double-blind and placebo-controlled. The study (AOD9604 peptide reviewaimed to identify whether the undesired effects, typically associated with hGH treatment were presented with AOD-9604 treatment. The side effects: increased IGF-1 levels, insulin resistance, impaired glucose tolerance. Blood samples were analysed to identify the presence of anti-AOD-9604 antibodies, to dismiss immunogenicity.


      Results:  Product AOD-9604 (AOD9604 peptide review) research  did not affect serum IGF-1 levels. AOD 9604 does not have an adverse effect on carbohydrate metabolism. Patients showed no presence of anti-AOD -9604 antibodies No withdrawal effects noted No serious adverse events related to AOD 9604 intake. Conclusion: AOD-9604 was shown to have a very good safety, and a safe tolerability profile and treatment did not result in any of the adverse effects seen in full – length hGH treatments


      AOD-9604 clinical library. Product Research shows:

      • Obesity drugs in clinical development.Halford JC.Curr Opin Investig Drugs. 2006 Apr;7(4):312-8. Review.PMID: 16625817
      • AOD-9604 Metabolic.Wilding J.Curr Opin Investig Drugs. 2004 Apr;5(4):436-40. Review.PMID: 15134286
      • The effects of human GH and its lipolytic fragment (AOD9604) on lipid metabolism following chronic treatment in obese mice and beta(3)-AR knock-out mice.Heffernan M, Summers RJ, Thorburn A, Ogru E, Gianello R, Jiang WJ, Ng FM.Endocrinology. 2001 Dec;142(12):5182-9.PMID: 11713213
      • Effect of Intra-articular Injection of AOD9604 with or without Hyaluronic Acid in Rabbit Osteoarthritis Model.Kwon DR, Park GY.Ann Clin Lab Sci. 2015 Summer;45(4):426-32.PMID: 26275694
      • Obesity: a review of currently used antiobesity drugs and new compounds in clinical development].Zieba R.Postepy Hig Med Dosw (Online). 2007 Oct 19;61:612-26. Review. Polish.PMID: 17971763
      • Increase of fat oxidation and weight loss in obese mice caused by chronic treatment with human growth hormone or a modified C-terminal fragment.Heffernan MA, Thorburn AW, Fam B, Summers R, Conway-Campbell B, Waters MJ, Ng FM.Int J Obes Relat Metab Disord. 2001 Oct;25(10):1442-9.PMID: 11673763
      • Metabolic studies of a synthetic lipolytic domain (AOD9604) of human growth hormone.Ng FM, Sun J, Sharma L, Libinaka R, Jiang WJ, Gianello R.Horm Res. 2000;53(6):274-8.PMID: 11146367

      AOD-9604 new articles

      Metabolic develops profitable marketing plans for AOD-9604
      https://technicality.me/2014/02/05/metabolic-develops- profitable-marketing- plans-for- aod-9604/

       

      Beware of Counterfeit

      The internet is full of counterfeit peptides and products of inferior quality. BIOV8 is committed to providing only the highest quality pharmaceutical  grade products and can provide proof of purity and sterility results. BIOV8 peptides are only prescribed by one of our qualified licensed practitioners which is required by law.

       

      *** Please note. All injectables come with a 50 pack of syringes.  If you're purchasing a vial we recommend purchasing a sharpies box for safe disposal. Buy as a single unit or in a bundle***